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Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line.

Author:
  • Catja Freiburghaus
  • Birgit Janicke
  • Helena Lindmark Månsson
  • Stina Oredsson
  • Marie Paulsson
Publishing year: 2009
Language: English
Pages: 2477-2484
Publication/Series: Journal of Dairy Science
Volume: 92
Issue: 6
Document type: Journal article
Publisher: American Dairy Science Association

Abstract english

Food components modify the risk of cancer at a large number of sites but the mechanism of action is unknown. In the present investigation, we studied the effect of the peptide lactoferricin derived from bovine milk lactoferrin on human colon cancer CaCo-2 cells. The cells were either untreated or treated with 2.0, 0.2, or 0.02 microM lactoferricin. Cell cycle kinetics were investigated with a bromodeoxyuridine DNA flow cytometric method. The results show that lactoferricin treatment slightly but significantly prolonged the S phase of the cell cycle. Lactoferricin treatment lowered the level of cyclin E1, a protein involved in the regulation of genes required for G(1)/S transition and consequently for efficient S phase progression. The slight prolongation of the S phase resulted in a reduction of cell proliferation, which became more apparent after a long treatment time.

Keywords

  • Zoology
  • Food Engineering

Other

Published
  • ISSN: 1525-3198
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid