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COMPRENDO: Focus and approach.

Author:
  • U Schulte-Oehlmann
  • T Albanis
  • A Allera
  • J Bachmann
  • Pia Berntsson
  • N Beresford
  • DC Carnevali
  • F Ciceri
  • T Dagnac
  • J Falandysz
  • S Galassi
  • D Hala
  • G Janer
  • R Jeannot
  • S Jobling
  • I King
  • D Klingmüller
  • W Kloas
  • KO Kusk
  • R Levada
  • S Lo
  • I Lutz
  • J Oehlmann
  • Stina Oredsson
  • C Porte
  • M Rand-Weaver
  • V Sakkas
  • M Sugni
  • C Tyler
  • R van Aerle
  • C van Ballegoy
  • L Wollenberger
Publishing year: 2006
Language: English
Pages: 98-100
Publication/Series: Environmental Health Perspectives
Volume: 114
Issue: Supplement 1
Document type: Journal article
Publisher: National Institute of Environmental Health Science

Abstract english

Tens of thousands of man-made chemicals are in regular use and discharged into the environment. Many of them are known to interfere with the hormonal systems in humans and wildlife. Given the complexity of endocrine systems, there are many ways in which endocrine-disrupting chemicals (EDCs) can affect the body's signaling system, and this makes unraveling the mechanisms of action of these chemicals difficult. A major concern is that some of these EDCs appear to be biologically active at extremely low concentrations. There is growing evidence to indicate that the guiding principle of traditional toxicology that "the dose makes the poison" may not always be the case because some EDCs do not induce the classical dose-response relationships. The European Union project COMPRENDO (Comparative Research on Endocrine Disrupters--Phylogenetic Approach and Common Principles focussing on Androgenic/Antiandrogenic Compounds) therefore aims to develop an understanding of potential health problems posed by androgenic and antiandrogenic compounds (AACs) to wildlife and humans by focusing on the commonalities and differences in responses to AACs across the animal kingdom (from invertebrates to vertebrates) .

Keywords

  • Environmental Health and Occupational Health
  • phylogenetic approach
  • wildlife exposure.
  • molecular screening
  • environmental health
  • antiandrogens
  • androgens
  • endocrine disruptor

Other

Published
  • ISSN: 1552-9924
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid