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Novel Pt(II) and Pd(II) complexes with polyamine analogues: Synthesis and vibrational analysis.

Author:
  • Tania Silva
  • Stina Oredsson
  • Lo Persson
  • P Woster
  • M P M Marques
Publishing year: 2012
Language: English
Pages: 1-7
Publication/Series: Journal of Inorganic Biochemistry
Volume: 108
Issue: March
Document type: Journal article
Publisher: Elsevier

Abstract english

A vibrational spectroscopy study (infrared and Raman) is reported for the biogenic polyamine analogues norspermidine (NSpd), N(1),N(11)-bis(ethyl)norspermine (BENSpm) and N(1)-cyclo-propylmethyl-N(11)-ethylnorspermine (CPENSpm), as well as for their newly synthesised Pt(II) and Pd(II) complexes. Attending to the potential antineoplastic properties of this kind of systems, their full conformational characterization is essential for understanding the molecular basis of their cytotoxic activity and the mechanisms through which they are transported into the cell. The all-trans geometry was found to be favoured for all the alkylated polyamines, in their totally protonated state, while their polynuclear complexes presented a stable geometry very similar to that previously obtained for the analogous chelates with spermidine (M(3)Spd(2)) and spermine (M(2)Spm), comprising two or three cisplatin-like (MCl(2)NH(2)) moieties.

Keywords

  • Pharmacology and Toxicology
  • Modified polyamines
  • Pt(II) / Pd(II) complexes
  • Raman spectroscopy
  • Infrared spectroscopy
  • Anticancer

Other

Published
  • Biogenic Amines
  • ISSN: 1873-3344
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid