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Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Author:
  • Björn Borgström
  • Xiaoli Huang
  • Martin Posta
  • Cecilia Hegardt
  • Stina Oredsson
  • Daniel Strand
Publishing year: 2013
Language: English
Pages: 9944-9946
Publication/Series: Chemical Communications
Volume: 49
Issue: 85
Document type: Journal article
Publisher: Royal Society of Chemistry

Abstract english

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

Keywords

  • Chemical Sciences

Other

Published
  • ISSN: 1364-548X
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid