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A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb

  • Eliana Maldonado
  • Daniel Svensson
  • Stina Oredsson
  • Olov Sterner
Publishing year: 2014
Language: English
Pages: 105-108
Publication/Series: Phytochemistry Letters
Volume: 8
Document type: Journal article
Publisher: Elsevier

Abstract english

A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.


  • Chemical Sciences
  • Zoology
  • Terpenoid
  • Structure elucidation
  • In vitro anticancer
  • Cytotoxicity


  • Vascular Physiology
  • ISSN: 1874-3900
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se


Functional zoology

+46 46 222 94 97



Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology


Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid