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Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells

Author:
  • Johannes Klose
  • Sarah Kattner
  • Björn Borgström
  • Claudia Volz
  • Thomas Schmidt
  • Martin Schneider
  • Stina Oredsson
  • Daniel Strand
  • Alexis Ulrich
Publishing year: 2018-01
Language: English
Pages: 53-59
Publication/Series: Biochemical and Biophysical Research Communications
Volume: 495
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

Salinomycin, a polyether antibiotic, is a well-known inhibitor of human cancer stem cells. Chemical modification of the allylic C20 hydroxyl of salinomycin has enabled access to synthetic analogs that display increased cytotoxic activity compared to the native structure. The aim of this study was to investigate the activity of a cohort of C20-O-acyl analogs of salinomycin on human colorectal cancer cell lines in vitro. Two human colorectal cancer cell lines (SW480 and SW620) were exposed to three C20-O-acylated analogs and salinomycin. The impact of salinomycin and its analogs on tumor cell number, migration, cell death, and cancer stem cell specifity was analyzed. Exposure of human colorectal cancer cells to the C20-O-acylated analogs of salinomycin resulted in reduced tumor cell number and impaired tumor cell migration at lower concentrations than salinomycin. When used at higher (micromolar) concentrations, these effects were accompanied by induction of apoptotic cell death. Salinomycin analogs further expose improved activity against cancer stem cells compared to salinomycin.

Keywords

  • Cell and Molecular Biology
  • Apoptosis
  • Cancer stem cells
  • Colorectal cancer
  • Salinomycin
  • Salinomycin analogs

Other

Published
  • ISSN: 0006-291X
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid