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Bivalent polyether ionophores : Synthesis and biological evaluation of C2-symmetric salinomycin dimers

  • Michał Antoszczak
  • Ewa Maj
  • Björn Borgström
  • Stina Oredsson
  • Adam Huczyński
  • Joanna Wietrzyk
  • Daniel Strand
Publishing year: 2017
Language: English
Pages: 2396-2399
Publication/Series: Tetrahedron Letters
Volume: 58
Issue: 24
Document type: Journal article
Publisher: Elsevier

Abstract english

Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.


  • Biochemistry and Molecular Biology
  • Anti-proliferative activity
  • Glaser-type coupling reaction
  • Ionophore antibiotics
  • Multivalent structures
  • SRB assay


  • ISSN: 0040-4039
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se


Functional zoology

+46 46 222 94 97



Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology


Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid