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Estimating the distribution of the G2 phase duration from flow cytometric histograms

Author:
  • Sara Larsson
  • Tobias Rydén
  • Ulla Holst
  • Stina Oredsson
  • Maria C Johansson
Publishing year: 2008
Language: English
Pages: 1-17
Publication/Series: Mathematical Biosciences
Volume: 211
Issue: 1
Document type: Journal article
Publisher: Elsevier

Abstract english

A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G2 phase duration. Two different model classes involving different assumptions on the distribution of the G2 phase duration are considered. Different assumptions of the G2 phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G2 phase duration are all in the same range.

Keywords

  • Cancer and Oncology
  • Cell cycle progression
  • Branching process
  • G2 phase duration
  • Flow cytometry

Other

Published
  • ISSN: 0025-5564
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid