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Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro

Author:
  • Johannes Ghatnekar
  • Margareta Hägerlöf
  • Stina Oredsson
  • Kersti Alm
  • Sofi Elmroth
  • Tina Persson
Publishing year: 2007
Language: English
Pages: 7426-7433
Publication/Series: Bioorganic & Medicinal Chemistry
Volume: 15
Issue: 23
Document type: Journal article
Publisher: Elsevier
Additional info: The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Functional Zoology (432112239), Biochemistry and Structural Biology (S) (000006142), Department of Biology (000016100), Organic chemistry (S/LTH) (011001240)

Abstract english

We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.

Keywords

  • Zoology
  • Modified nucleoside
  • Adenosine
  • Uridine
  • Polyamine derivatives

Other

Published
  • ISSN: 0968-0896
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid