Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics. Synthesis and toxicity evaluation in breast cancer cell lines.

Author:
  • Sophie Manner
  • Viveca Oltner
  • Stina Oredsson
  • Ulf Ellervik
  • Torbjörn Frejd
Publishing year: 2013
Language: English
Pages: 7134-7144
Publication/Series: Organic and Biomolecular Chemistry
Volume: 11
Issue: 41
Document type: Journal article
Publisher: Royal Society of Chemistry

Abstract english

Paclitaxel is one of the most important anti-cancer agents introduced during the last 20 years. However, the use of paclitaxel is limited by undesirable side effects as well as the development of drug resistance. Here, we report a synthetic strategy towards spiro-bicyclo[2.2.2]octane derivatives, which includes double Michael addition and ring-closing metathesis as key synthetic steps. This strategy was used to synthesize a series of spiro-bicyclic compounds designed to be paclitaxel mimetics, which were evaluated in human breast-derived cell lines. One of these paclitaxel mimetics showed toxicity, although at higher concentrations than paclitaxel itself. In addition, two other spiro-bicyclic compounds, lacking the paclitaxel side chain, showed toxicity.

Keywords

  • Zoology
  • Chemical Sciences

Other

Published
  • ISSN: 1477-0539
Stina Oredsson
E-mail: stina [dot] oredsson [at] biol [dot] lu [dot] se

Professor

Functional zoology

+46 46 222 94 97

B-C208

4

Principal investigator

LUCC - Lund University Cancer Centre

Research group

Animal Physiology

Projects

Cell proliferation

Doctoral students and postdocs

PhD Students, main supervisor

Wendy Soria Sotillo

PhD Students, assistant supervisor

Atena Malakpour Permlid