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Parallel telomere shortening in multiple body tissues owing to malaria infection

Author:
  • Muhammad Asghar
  • Vaidas Palinauskas
  • Nadège Zaghdoudi-Allan
  • Gediminas Valkiūnas
  • Andrey Mukhin
  • Elena Platonova
  • Anna Färnert
  • Staffan Bensch
  • Dennis Hasselquist
Publishing year: 2016-08-17
Language: English
Publication/Series: Proceedings of the Royal Society B: Biological Sciences
Volume: 283
Issue: 1836
Document type: Journal article
Publisher: Royal Society

Abstract english

Several studies have shown associations between shorter telomere length in blood and weakened immune function, susceptibility to infections, and increased risk of morbidity and mortality. Recently, we have shown that malaria accelerates telomere attrition in blood cells and shortens lifespan in birds. However, the impact of infections on telomere attrition in different body tissues within an individual is unknown. Here, we tested whether malarial infection leads to parallel telomere shortening in blood and tissue samples from different organs. We experimentally infected siskins (Spinus spinus) with the avian malaria parasite Plasmodium ashfordi, and used real-time quantitative polymerase chain reaction (PCR) to measure telomere length in control and experimentally infected siskins. We found that experimentally infected birds showed faster telomere attrition in blood over the course of infection compared with control individuals (repeatedly measured over 105 days post-infection (DPI)). Shorter telomeres were also found in the tissue of all six major organs investigated (liver, lungs, spleen, heart, kidney, and brain) in infected birds compared with controls at 105 DPI. To the best of our knowledge, this is the first study showing that an infectious disease results in synchronous telomere shortening in the blood and tissue cells of internal organs within individuals, implying that the infection induces systemic stress. Our results have far-reaching implications for understanding how the short-term effects of an infection can translate into long-term costs, such as organ dysfunction, degenerative diseases, and ageing.

Keywords

  • Journal Article

Other

Published
  • Malaria in birds
  • Immunoecology
  • Molecular Ecology and Evolution Lab
  • ISSN: 1471-2954
Staffan Bensch
E-mail: staffan [dot] bensch [at] biol [dot] lu [dot] se

Professor

MEMEG

+46 46 222 42 92

E-C213

Sölvegatan 37, Lund

50

Head of unit

MEMEG

+46 46 222 42 92

E-C213

Sölvegatan 37, Lund

50

Research group

Molecular Ecology and Evolution Lab

Projects

Doctoral students and postdocs

PhD students, main supervisor

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