Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs

  • Olena Prykhodko
  • Olexandr Fedkiv
  • Stefan Pierzynowski
  • J. Svendsen
  • B. R. Westrom
Publishing year: 2010
Language: English
Pages: 253-256
Publication/Series: Livestock Science
Volume: 133
Issue: 1-3
Document type: Conference paper
Publisher: Elsevier

Abstract english

The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocation by studying changes in the blood/plasma levels of major gut hormones, immune parameters and acute phase proteins. Suckling, 9-10 day-old, littermate piglets were gavage fed PHA, either in purified or crude form or, as a control, alpha-lactalbumin (n = 5-6 pigs/group) and blood was obtained repeatedly during one week and after weaning at 5 weeks. No significant differences in the blood parameters between PHA-treated pigs in comparison to their time-matched controls were found during the first week after treatment. At weaning significant changes in hormonal (insulin) and immune (WBC) parameters and CRP were observed, however, these effects were independent of earlier PHA treatment. In conclusion, PHA, given enterally as a single dose, did not affect the basal blood parameters analysed, during both the suckling and post-weaning periods in piglets. (C) 2010 Elsevier B.V. All rights reserved.


  • Zoology
  • Inflammation
  • Phytohaemagglutinin
  • Weaning
  • Intestinal maturation
  • Piglets


11th International Symposium on Digestive Physiology of Pigs
2009-05-20 - 2009-05-22
Costa Daurada, Spain
  • ISSN: 1871-1413
E-mail: olexandr [dot] fedkiv [at] food [dot] lth [dot] se

Project assistant

Department of Food Technology, Engineering and Nutrition

+46 46 222 96 74

+46 72 550 12 26


Research group

Animal Physiology


Gut Biology