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Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile

Author:
  • S V Allander
  • N N Nupponen
  • Markus Ringnér
  • G Hostetter
  • G W Maher
  • N Goldberger
  • Y Chen
  • J Carpten
  • A G Elkahloun
  • P S Meltzer
Publishing year: 2001
Language: English
Pages: 8624-8628
Publication/Series: Cancer Research
Volume: 61
Issue: 24
Document type: Journal article
Publisher: American Association for Cancer Research Inc.

Abstract english

Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors of the digestive tract, are believed to arise from the interstitial cells of Cajal. GISTs are characterized by mutations in the proto-oncogene KIT that lead to constitutive activation of its tyrosine kinase activity. The tyrosine kinase inhibitor STI571, active against the BCR-ABL fusion protein in chronic myeloid leukemia, was recently shown to be highly effective in GISTs. We used 13,826-element cDNA microarrays to define the expression patterns of 13 KIT mutation-positive GISTs and compared them with the expression profiles of a group of spindle cell tumors from locations outside the gastrointestinal tract. Our results showed a remarkably distinct and uniform expression profile for all of the GISTs. In particular, hierarchical clustering of a subset of 113 cDNAs placed all of the GIST samples into one branch, with a Pearson correlation >0.91. This homogeneity suggests that the molecular pathogenesis of a GIST results from expansion of a clone that has acquired an activating mutation in KIT without the extreme genetic instability found in the common epithelial cancers. The results provide insight into the histogenesis of GIST and the clinical behavior of this therapeutically responsive tumor.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 1538-7445
Markus Ringnér
E-mail: markus [dot] ringner [at] biol [dot] lu [dot] se

Research engineer

Molecular Cell Biology

B-A314c

Sölvegatan 35, Lund

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