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Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

  • Sofia Gruvberger
  • Markus Ringnér
  • Yidong Chen
  • Sujatha Panavally
  • Lao Saal
  • Mårten Fernö
  • Carsten Peterson
  • Paul S. Meltzer
  • Åke Borg
Publishing year: 2001
Language: English
Pages: 5979-5984
Publication/Series: Cancer Research
Volume: 61
Issue: 16
Document type: Journal article
Publisher: American Association for Cancer Research Inc.

Abstract english

To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast carcinomas discordant for ER status were determined using DNA microarray technology. Using artificial neural networks as well as standard hierarchical clustering techniques, the tumors could be classified according to ER status, and a list of genes which discriminate tumors according to ER status was generated. The artificial neural networks could accurately predict ER status even when excluding top discriminator genes, including ER itself. By reference to the serial analysis of gene expression database, we found that only a small proportion of the 100 most important ER discriminator genes were also regulated by estradiol in MCF-7 cells. The results provide evidence that ER+ and ER- tumors display remarkably different gene-expression phenotypes not solely explained by differences in estrogen responsiveness.


  • Cancer and Oncology


  • Personalized Breast Cancer Treatment
  • ISSN: 1538-7445
Markus Ringnér
E-mail: markus [dot] ringner [at] biol [dot] lu [dot] se

Research engineer

Molecular Cell Biology


Sölvegatan 35, Lund