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Microarray-based cancer diagnosis with artificial neural networks

Author:
  • Markus Ringnér
  • Carsten Peterson
Publishing year: 2003
Language: English
Pages: 30-30
Publication/Series: BioTechniques
Volume: 34
Issue: Suppl
Document type: Journal article review
Publisher: Informa Healthcare

Abstract english

In recent years, the advent of experimental methods top robe gene expression profiles of cancer on a genome-wide scale has led to widespread use of supervised machine learning algorithms to characterize these profiles. The main applications of these analysis methods range from assigning functional classes of previously uncharacterized genes to classification and prediction of different cancer tissues. This article surveys the application of machine learning algorithms to classification and diagnosis of cancer based on expression profiles. To exemplify the important issues of the classification procedure, the emphasis of this article is on one such method, namely artificial neural networks. In addition, methods to extract genes that are important for the performance of a classifier, as well as the influence of sample selection on prediction results are discussed.

Keywords

  • Biophysics

Other

Published
  • ISSN: 0736-6205
Markus Ringnér
E-mail: markus [dot] ringner [at] biol [dot] lu [dot] se

Research engineer

Molecular Cell Biology

B-A317

Sölvegatan 35, Lund

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