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Non-Lamellar lipid assembly at interfaces : Controlling layer structure by responsive nanogel particles

  • Aleksandra P. Dabkowska
  • Maria Valldeperas Badell
  • Christopher Hirst
  • Costanza Montis
  • Gunnar K. Pálsson
  • Meina Wang
  • Sofi Nöjd
  • Luigi Gentile
  • Justas Barauskas
  • Nina Juliane Steinke
  • Gerd E. Schroeder-Turk
  • Sebastian George
  • Maximilian W A Skoda
  • Tommy Nylander
Publishing year: 2017
Language: English
Publication/Series: Interface Focus
Volume: 7
Issue: 4
Document type: Journal article
Publisher: Royal Society Publishing

Abstract english

Biological membranes do not only occur as planar bilayer structures, but depending on the lipid composition, can also curve into intriguing threedimensional structures. In order to fully understand the biological implications as well as to reveal the full potential for applications, e.g. for drug delivery and other biomedical devices, of such structures, well-defined model systems are required. Here, we discuss the formation of lipid nonlamellar liquid crystalline (LC) surface layers spin-coated from the constituting lipids followed by hydration of the lipid layer. We demonstrate that hybrid lipid polymer films can be formed with different properties compared with the neat lipid LC layers. The nanostructure and morphologies of the lipid films formed reflect those in the bulk. Most notably, mixed lipid layers, which are composed of glycerol monooleate and diglycerol monooleate with poly(N-isopropylacrylamide) nanogels, can form films of reverse cubic phases that are capable of responding to temperature stimulus. Owing to the presence of the nanogel particles, changing the temperature not only regulates the hydration of the cubic phase lipid films, but also the lateral organization of the lipid domains within the lipid self-assembled film. This opens up the possibility for new nanostructured materials based on lipid-polymer responsive layers.


  • Polymer Chemistry
  • Physical Chemistry
  • Cubic bicontinuous phases
  • Lipid non-lamellar liquid crystalline
  • Microgel
  • Nanogel
  • Neutron reflectivity
  • Responsive lipid layers


  • ISSN: 2042-8898
Luigi Gentile
E-mail: luigi [dot] gentile [at] fkem1 [dot] lu [dot] se




Sölvegatan 37, Lund


Visiting research fellow

Physical Chemistry

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Research group

Microbial Ecology