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Life before LUCA

Molecular Cell Biology Seminars

Athel Cornish-Bowden, from CNRS in France, will give a talk about "Life before LUCA".

Abstract

In this seminar I shall present our vision of LUCA and why we think that it is an entity much more recent than the first living systems. This raises the question of what a living system is, and I shall briefly discuss several theories of life: (M,R)-systems (Robert Rosen), autopoiesis (Humberto Maturana and Francisco Varela), chemotons (Tibor Gánti), autocatalytic sets (Freeman Dyson and Stuart Kauffman), and hypercycles (Manfred Eigen and Peter Schuster).

I shall finish by presenting a deterministic computer model of a very simple (M,R)- system that shows that it can maintain a steady state indefinitely and recreate it after a catastrophic collapse. A stochastic version of the model has similar properties, but cannot survive for infinite time. Study of the stochastic system suggests that there is a limiting cell-size below which self-organization is impossible. With reasonable estimates of the kinetic parameters this limit is about 0.01% of the volume of a bacterial cell.

Time: 
19 April 2018 15:15
Location: 
Biology Lecture Hall, Biology Bld A, Sölvegatan 35, Lund
Contact: 
Lars.Hederstedt [at] biol.lu.se

About the event

Time: 
19 April 2018 15:15
Location: 
Biology Lecture Hall, Biology Bld A, Sölvegatan 35, Lund
Contact: 
Lars.Hederstedt [at] biol.lu.se