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Iron-sulfur cluster proteins as biological switches

A metal switch with a green label on and a red label off.
Thursday Biology Seminar

Nick Le Brun, from University of East Anglia in UK, will give a talk about "Iron-sulfur cluster proteins as biological switches".

Brief description of research

In cells, iron-sulfur cluster proteins carry out multiple functions, including as regulators of gene transcription/translation in response to environmental stimuli. In all known cases, the cluster acts as the sensory module, where the inherent reactivity/fragility of iron-sulfur clusters with small/redox active molecules is exploited to effect conformational changes that modulate binding to DNA regulatory sequences. This promotes an often substantial re-programming of the cellular proteome that enables the organism or cell to adapt to, or counteract, its changing circumstances.

Here, I will discuss recent progress in the structural and mechanistic characterization of iron-sulfur cluster regulators, focussing on FNR, NsrR, RirA and WhiB-like proteins that are involved in sensing molecular oxygen, iron, and/or nitric oxide in bacteria. In recent years, we have developed the use of mass spectrometry under conditions where iron-sulfur proteins remain folded and the cluster bound; aspects of this work will be discussed.

Time: 
20 September 2018 13:15 to 14:15
Location: 
Blue Hall, Ecology building, Sölvegatan 37, Lund
Contact: 
Lars.Hederstedt [at] biol.lu.se

About the event

Time: 
20 September 2018 13:15 to 14:15
Location: 
Blue Hall, Ecology building, Sölvegatan 37, Lund
Contact: 
Lars.Hederstedt [at] biol.lu.se