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Atena Malakpour Permlid

Doctoral Researcher

I am from the northern part of Iran, near the coast of the Caspian Sea. I studied Microbiology for my undergraduate degree in Iran and continued to get a master degree in molecular biology at Lund University in 2013. My motivation for being a part of molecular biology field lies in the fact that it is a foundation of our capability to treat almost all human diseases. I got the opportunity to work with some new anti-cancer compounds and their inhibitory effect on NF-κB signaling pathway in breast cancer cells during my master studies. Right after graduation, I was accepted as a PhD candidate under the supervision of professor Stina Oredsson and Per Fredrik Johansson in Biology department, Lund University in 2016.

Recent findings have shown that cells often exhibit different behaviour when they are separated from their native three dimensional (3D) tissues and confined to a monolayer cell cultures (2D). The development of complex synthetic 3D cell culture models, which can mimic the native extracellular matrix, represent an important step towards a more in vivo-like cell culture system.

In my project, we are working on the development of a unique 3D cell culture model using different types of polymers such as polycaprolactone (PCL) and polylactide (PLA). A modified electrospinning method is utilized to fabricate highly porous 3D nanofiber scaffolds, mimicking the collagen fibres of the extracellular matrix. We also investigate the proliferation and migration of primarily various breast cancer cell lines and other cells such as fibroblasts, immune cells and co-culture of such cells in randomly-oriented and aligned fibre scaffolds. The effect of different new anti-cancer compounds on the cancer cells and cancer stem cells proliferation and migration will be investigated as well. Beside using 3D systems as excellent alternative in vivo models, we are replacing medium supplemented with donor horse serum instead of the commonly used but animal ethically questionable fetal calf serum in this project. Our goal is to contribute to 3R principles (replacing, refining and reducing the use of animals) in cancer research in future.

 

www.eacr.org/news/image-of-the-month-may-2017

Publications

Retrieved from Lund University's publications database

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Publications

Retrieved from Lund University's publications database

Publications

Retrieved from Lund University's publications database

Page Manager:
Atena Malakpour
E-mail: atena [dot] malakpour_permlid [at] biol [dot] lu [dot] se

Doctoral student

Functional zoology

+46 76 82 05 37

B-C224

Sölvegatan 35, Lund, Lund

4

Doctoral student

NanoLund

14

Doctoral Researcher

Research group

Animal Physiology

Supervisors

Main supervisor

Stina Oredsson

Assistant supervisor

Per Fredrik Johansson