Lund University is celebrating 350 years. Read more on lunduniversity.lu.se

Menu

Javascript is not activated in your browser. This website needs javascript activated to work properly.
You are here

Transgenerational effects of caloric restriction on appetite: a meta-analysis

Author:
  • M Lagisz
  • H Blair
  • P Kenyon
  • Tobias Uller
  • D Raubenheimer
  • Shinichi Nakagawa
Publishing year: 2014
Language: English
Pages: 294-309
Publication/Series: Obesity Reviews
Volume: 15
Issue: 4
Document type: Journal article
Publisher: Wiley-Blackwell

Abstract english

Maternal undernutrition can result in significant alterations to the post-natal offspring phenotype, including body size and behaviour. For example, maternal food restriction has been implicated in offspring hyperphagia, potentially causing increased weight gain and fat accumulation. This could result in obesity and other adverse long-term health effects in offspring. We investigated the link between maternal caloric restriction during gestation and offspring appetite by conducting the first meta-analysis on this topic using experimental data from mammalian laboratory models (i.e. rats and mice). We collected 89 effect sizes from 35 studies, together with relevant moderators. Our analysis revealed weak and statistically non-significant overall effect on offspring's appetite. However, we found that lower protein content of restricted diets is associated with higher food intake in female offspring. Importantly, we show that a main source of variation among studies arises from whether, and how, food intake was adjusted for body mass. This probably explains many of the contradictory results in the field. Based on our results, we recommend using allometric scaling of food intake to body mass in future studies.

Keywords

  • Biological Sciences

Other

Published
  • ISSN: 1467-7881
Tobias Uller
E-mail: tobias.uller [at] biol.lu.se

Professor

Evolutionary ecology

+46 46 222 30 94

E-C256

Sölvegatan 37, Lund

50

Research group

Experimental Evolution, Ecology & Behaviour

Projects

Doctoral students and postdocs

I am currently about to move to Lund from University of Oxford. For details about DPhil students and postdocs in my previous research group based at the Edward Grey Institute, please click here

Downloads & links

CV (pdf; 241 kB)