Sex-chromosome evolution, epistasis, and sexual antagonism
My main research areas are sexual antagonism (genetic variants beneficial to one sex but harmful to the other) and sex chromosome evolution, which I am investigating in two separate projects. I am using fruit flies (Drosophila melanogaster) as the study organism in both projects.
The first project will look at the role of sexually antagonistic variation on the X-chromosome through a female-limited X-chromosome evolution experiment. By using an FM balancer chromosome I will be able to force the transmission of the same X-chromosome to be female-limited for many generations and thereby eliminating male-specific selection on the X-chromosome. The aim is to determine the magnitude of the response to female-limited X-chromosome evolution and which traits respond to selection.
The second project is to quantify coevolution of the X and Y chromosome through a sex chromosome replacement experiment. By using CG flies I am able to pair sex chromosomes from a number of different D. melanogaster stocks together in novel combinations. This is the first experiment to address coevolution of the sex chromosomes in D. melanogaster and the theory that Y-chromosome polymorphism is maintained by sexual antagonism on the X-chromosome.
- Female-limited X-chromosome evolution inDrosophila melanogaster (Fruit fly)
- Sex chromosome replacement experiment in Drosophila melanogaster (Fruit fly)
- Genotype-by-environment effects on sperm traits