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Estimating signs of selection in genes and genomes - June 13-15, 2017, Lund

 

Estimating signs of selection in genes and genomes - June 13-15, 2017, Lund

Only 2% of our genome encodes proteins but these genes are often of key interest for ecologists and evolutionary biologists when studying adaptation and evolution. In this course, you will learn how to detect signs of positive and negative selection both in single genes and in genomes. Maria Anisimova will be our teacher and she is very experienced working with, for example, selection in a phylogenetic framework and measuring evolutionary rates. At present Maria is Head of Applied Computational Genomics at Zurich Univerity of Applied Sciences.
Cost: Geneco PhD students and students/researchers enrolled at Lund University Faculty of Science free of charge. Others SEK 1000 + VAT.
Credits: ECTS 1,5 points/ 1,5 hp

Two themes over three days

Modeling molecular evolution and phylogenetics

  • Markov models of substitutions
  • Hypothesis testing and model selection
  • Data formats and visualisation
  • Phylogenetic inference
  • ML tree inference: Exercises with PHYML  

Detecting positive selection with codon models

  • Natural selection and codon models 
  • Exercises with PAML (basics, one ratio model)
  • Modeling variability of selection 
  • Exercises with PAML (branch models)
  • Site models, detecting residues under selection
  • Exercises with PAML (site models)

Register here!

Deadline for registration: May 2, 2017.

Contact

General questions

Helena Westerdahl
Associate professor
MEMEG

Telephone: +46 46 222 36 69
E-mail: Helena.Westerdahl [at] biol.lu.se

Questions regarding GENECO courses

Bengt Hansson
Associate professor
MEMEG

Telephone: +46 46222 49 96
E-mail: Bengt.Hansson [at] biol.lu.se

Questions regarding administration, economy and other practical issues

Christina Rengefors
Project assistant
Department of Biology

Telephone: +46 46 222 96 14
E-mail: Christina.Rengefors [at] biol.lu.se